API's
Active Pharmaceutical Ingredients
Active Pharmaceutical Ingredients
API
BP/USP
C11H14N4O4
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
69975-86-6
266 g/mol
Methylxanthines
Phosphodiesterase Inhibitor
| Appearance | Off-White Crystalline Solid |
|---|---|
| Solubility | Slightly soluble in water, soluble in ethanol |
| Melting point | 216-218°C |
| pH | 4.0 – 6.0 |
Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, Doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies. In contrast with other xanthine derivatives, Doxofylline does not significantly bind to adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. Decreased affinity for adenosine receptors may account for the better safety profile of Doxofylline compared to theophylline.
Doxofylline works as a bronchodilator by inhibiting the enzyme phosphodiesterase, particularly PDE4, which increases intracellular cyclic AMP (cAMP) levels, leading to relaxation of bronchial smooth muscles and improved airflow. Unlike theophylline, it has minimal effect on adenosine receptors, resulting in fewer side effects such as palpitations and insomnia. Additionally, it has mild anti-inflammatory properties, making it effective in managing asthma and chronic obstructive pulmonary disease (COPD).
| Attribute | Why Salius Pharma Is a Good Choice |
|---|---|
| Quality Certification | WHO GMP, ISO 9001:2015, FDA audited facilities |
| Affordability & Generic Access | Cost competitive generics for global supply |
| Export Experience | Proven track record of supplying globally |
When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.
We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.
7 to 21 business days from dispatch, depending on your location.
Doxofylline is used to relieve nausea, vomiting, bloating, and improve gastric motility in conditions like gastroparesis and reflux.
Doxofylline works by inhibiting phosphodiesterase enzymes, which increases the levels of cyclic AMP (cAMP) inside bronchial smooth muscle cells, leading to muscle relaxation and bronchodilation; it also has anti-inflammatory effects and minimal interaction with adenosine receptors, reducing side effects compared to other xanthines.
Yes, it generally has fewer side effects and lower toxicity risk compared to theophylline.
Yes, exporters must comply with country-specific regulations, provide Certificates of Analysis (CoA), Certificates of Origin (CoO), and may require Drug Master Files (DMF) for regulatory approval in importing countries
Yes, Salius Pharma exports Doxofylline API to several African countries. As part of its global expansion strategy, Salius Pharma is actively engaged in supplying high-quality pharmaceutical ingredients to various regions, including Africa. The company has established a presence in countries such as Nigeria, Kenya, South Africa, Ethiopia, and Ghana, among others.
Looking to source Doxofylline or other high-quality pharmaceutical products? We’re here to help. Whether you need Active Pharmaceutical Ingredients (APIs), finished formulations, or regulatory support, our team is ready to provide dependable, compliant, and cost-effective solutions tailored to your market needs.