Amlodipine Besylate

Synonyms

• Amlodipine, Amlodipine free base, Amlodipino, Amlodipinum

PHYSIOCHEMICAL PROPERTIES

Product Description

Amlodipine is a calcium channel blocker used to treat hypertension and angina.
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers.

How Amlodipine Besylate Works

Mechanism of action on blood pressure

Amlodipine is considered a peripheral arterial vasodilator that exerts its action directly on vascular smooth muscle to lead to a reduction in peripheral vascular resistance, causing a decrease in blood pressure.

Mechanism of action in angina

The exact mechanism by which amlodipine relieves the symptoms of angina have not been fully elucidated to this date; however, the mechanism of action is likely twofold:

Amlodipine has a dilating effect on peripheral arterioles, reducing the total peripheral resistance (afterload) against which the cardiac muscle functions.

Dilatation of the main coronary arteries and coronary arterioles, both in healthy and ischemic areas, is another possible mechanism of amlodipine reduction of blood pressure.

Use(s)

• Hypertension
• Coronary artery disease
• Chronic stable angina

Adverse Effects

• Peripheral vasodilatation with the possibility of reflex tachycardia
• Prolonged hypotension leading to shock

Why choose Salius for Amlodipine Besylate?

1. Committed to Global Manufacturing Excellence
   Salius strictly follows WHO-GMP standards across all facilities, with select sites also approved by the U.S. FDA. Every production batch is tested in state-of-the-art laboratories to ensure consistent quality and patient safety.
2. Scalable and Cost-Efficient API Solutions
   Salius delivers high-quality Active Pharmaceutical Ingredients (APIs) at globally competitive prices. With strong capabilities in high-volume manufacturing and reliable export logistics, we support affordable sourcing for pharmaceutical companies in value-driven markets.
3. Global Export Expertise and Comprehensive Documentation Support
   Salius has experience exporting APIs worldwide, offering full regulatory documentation including Drug Master Files (DMF) and impurity profiles. We provide dedicated support for regulatory filings to help international clients, even in highly regulated markets, ensure smooth approval and compliance.

4. Proven Reliability
   Salius Pharma is presented as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Amlodipine Besylate
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.