Caffeine

Synonyms

• 1-Methyltheobromine, 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion, 7-Methyltheophylline, Anhydrous caffeine

PHYSIOCHEMICAL PROPERTIES

Product Description

Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine.

How Caffeine Works

Respiratory System:

Enhances respiratory drive by stimulating the brain’s response to CO₂ and increasing diaphragm contractility—used in treating apnea of prematurity.

Central Nervous System:

Blocks all four adenosine receptor subtypes (A1, A2a, A2b, A3); alertness effects are mainly due to A2a receptor antagonism.

Renal System:

Acts as a diuretic by increasing renal blood flow, glomerular filtration, and sodium excretion.

Cardiovascular System:

Increases heart activity via adenosine receptor blockade and catecholamine release. Causes both vasodilation (via nitric oxide) and vasoconstriction (via catecholamines), raising systolic blood pressure and relieving migraine by constricting dilated brain vessels.

Use(s)

• Stimulant: Improves alertness, concentration, and reduces fatigue.
• Treatment of apnea in premature infants: Stimulates the respiratory center to reduce episodes of apnea.
• Headache and migraine relief: Used in combination with pain relievers due to its vasoconstrictive effects.
• Enhancing athletic performance: Boosts endurance and reduces perceived effort.

Adverse Effects

• Insomnia and sleep disturbances
• Increased heart rate (tachycardia)
• Nausea, stomach upset
• Increased urination

Why choose Salius for Caffeine?

1. Trusted Manufacturing with Global Quality Standards
   Salius complies with WHO-GMP across all facilities, with select sites also approved by the U.S. FDA. Every batch undergoes rigorous laboratory testing to guarantee safety, quality, and full regulatory compliance.
2. Large-Scale API Production with Competitive Pricing
   Leveraging extensive manufacturing capacity and efficient global distribution, Salius delivers high-quality APIs at competitive prices, supporting pharmaceutical companies in cost-sensitive markets worldwide.
3. Global Export Expertise and Comprehensive Documentation Support
   Salius has experience exporting APIs worldwide, offering full regulatory documentation including Drug Master Files (DMF) and impurity profiles. We provide dedicated support for regulatory filings to help international clients, even in highly regulated markets, ensure smooth approval and compliance.

4. Proven Reliability
   Salius Pharma is presented as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Caffeine
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.