Carvedilol

Synonyms

• (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol, Carvedilol, Carvédilol, Carvedilolum

PHYSIOCHEMICAL PROPERTIES

Product Description

Carvedilol is a non-selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.

How Carvedilol Works

Carvedilol inhibits exercise, induced tachycardia through its inhibition of beta adrenoceptors. Carvedilol's action on alpha-1 adrenergic receptors relaxes smooth muscle in vasculature, leading to reduced peripheral vascular resistance and an overall reduction in blood pressure. At higher doses, calcium channel blocking and antioxidant activity can also be seen. The antioxidant activity of carvedilol prevents oxidation of low-density lipoprotein and its uptake into coronary circulation.

Use(s)

• Treat mild to severe heart failure

Adverse Effects

• Hypotension
• Bradycardia
• Cardiac insufficiency
• Cardiogenic shock

Why choose Salius for Carvedilol?

1. Trusted Manufacturing with Global Quality Standards
   Salius complies with WHO-GMP across all facilities, with select sites also approved by the U.S. FDA. Every batch undergoes rigorous laboratory testing to guarantee safety, quality, and full regulatory compliance.
2. Large-Scale API Production with Competitive Pricing
   Leveraging extensive manufacturing capacity and efficient global distribution, Salius delivers high-quality APIs at competitive prices, supporting pharmaceutical companies in cost-sensitive markets worldwide.
3. Global Export Expertise and Comprehensive Documentation Support
   Salius has experience exporting APIs worldwide, offering full regulatory documentation including Drug Master Files (DMF) and impurity profiles. We provide dedicated support for regulatory filings to help international clients, even in highly regulated markets, ensure smooth approval and compliance.

4. Proven Reliability
   Salius Pharma is presented as a government-recognized star export house with strong quality and delivery ratings.

What You Receive in Our Package

When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.

Each Shipment Includes:

Product

• Carefully packed Carvedilol
• Sealed in moisture-resistant, tamper-evident packaging
• Custom drum sizes or blister/bottle formats based on your order

Expected Delivery Time

We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.

Overall Delivery Time:

7 to 21 business days from dispatch, depending on your location.