API's
Active Pharmaceutical Ingredients
Active Pharmaceutical Ingredients
API
USP/EP
Cl2H6N2Pt
(SP-4-2)-diamminedichloroplatinum(II)
15663-27-1
300.05 g/mol
Platinum Coordination Complex
Anti-Cancer
| Appearance | Yellow to orange crystalline powder |
|---|---|
| Solubility | Slightly soluble in water, soluble in dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), insoluble in most organic solvents (e.g., ethanol, chloroform) |
| Melting point | ~270 °C |
| pH | 4.0 to 7.0 |
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
| Attribute | Why Salius Pharma Is a Good Choice |
|---|---|
| Quality Certification | WHO-GMP, ISO 9001:2015, FDA-audited facilities |
| Affordability & Generic Access | Cost-competitive generics for global supply |
| Export Experience | Proven record of supplying globally |
When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.
We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.
7 to 21 business days from dispatch, depending on your location.
Cisplatin is widely used in oncology for the treatment of various cancers. It is most prescribed for testicular cancer, ovarian cancer, bladder cancer, lung cancer (especially non-small cell and small cell types), head and neck cancers, and cervical cancer. It is often part of combination chemotherapy regimens.
Salius Pharma supports market entry by providing full regulatory documentation, including Drug Master Files (DMFs), Certificates of Analysis (CoAs), and CTD/eCTD dossiers, customized for the requirements of health authorities in African countries.
Cisplatin can cause nephrotoxicity (kidney damage), ototoxicity (hearing loss), and neurotoxicity. Patients should be well hydrated before and after administration to reduce renal toxicity. Regular monitoring of renal function, electrolytes, and hearing is essential. Caution is advised in elderly patients and those with preexisting kidney disease.
Cisplatin works by forming platinum-DNA adducts that interfere with DNA replication and transcription, leading to apoptosis (cell death) in rapidly dividing cancer cells. It is classified as an alkylating-like agent and exerts its effect in a cell cycle–nonspecific manner.
Common side effects include nausea, vomiting, loss of appetite, and fatigue. Serious side effects include kidney toxicity, hearing loss, nerve damage, and bone marrow suppression. Electrolyte imbalances (low magnesium, potassium, and calcium) are also frequent and should be corrected promptly.
Looking to source Cisplatin or other high-quality pharmaceutical products? We’re here to help. Whether you need Active Pharmaceutical Ingredients (APIs), finished formulations, or regulatory support, our team is ready to provide dependable, compliant, and cost-effective solutions tailored to your market needs.