API's
Active Pharmaceutical Ingredients
Active Pharmaceutical Ingredients
API
BP/EP
C22H24ClN5O2 · C4H4O4
(5-chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one) maleate
83898-65-1
477.92 g/mol
Benzimidazole derivatives
Anti-Emetic
| Appearance | Off-White Crystalline Solid |
|---|---|
| Solubility | Soluble in methanol, ethanol & slightly soluble in water |
| Melting point | 240–245 °C |
| pH | 4.0 – 5.5 |
Domperidone maleate is a medication primarily used as an antiemetic and a prokinetic agent. It is marketed under various trade names such as Motilium, Motilidone, and Costi. This drug is particularly effective in treating nausea and vomiting, dyspepsia, and gastroparesis, which is a condition where the stomach cannot empty itself in a normal fashion.
Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the Chemoreceptor Trigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of the gastrointestinal tract. Due to its weak penetration across the blood-brain barrier, Domperidone has almost no effect on the dopaminergic receptors in the brain, therefore, excluding psychotropic and neurologic side effects. Domperidone restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylorus. Domperidone also increases esophageal peristalsis and lower esophageal sphincter pressure and thus prevents regurgitation of gastric content.
| Attribute | Why Salius Pharma Is a Good Choice |
|---|---|
| Quality Certification | WHO GMP, ISO 9001:2015, FDA audited facilities |
| Affordability & Generic Access | Cost competitive generics for global supply |
| Export Experience | Proven track record of supplying globally |
When you order from Salius Pharma, you receive more than just a product — you receive a complete, professionally prepared package that meets international regulatory and quality expectations.
We ensure prompt and reliable shipping worldwide. Delivery times vary depending on destination, order volume, and regulatory requirements.
7 to 21 business days from dispatch, depending on your location.
Domperidone maleate is used to relieve nausea, vomiting, bloating, and improve gastric motility in conditions like gastroparesis and reflux.
It blocks dopamine D₂ receptors in the gut and brain (specifically the chemoreceptor trigger zone), helping reduce nausea and improve stomach emptying.
Domperidone is the active drug itself, while Domperidone maleate is its maleate salt form, made to improve solubility and absorption without changing the drug’s effect.
Yes, but avoid combining it with drugs that prolong the QT interval (heart rhythm) unless advised by a doctor.
Yes, Salius Pharma exports Domperidone maleate API to several African countries, including Nigeria, Kenya, South Africa, Ghana, Ethiopia, and Tanzania. The company has a strategic expansion plan targeting these and other regions, aiming to provide high-quality Active Pharmaceutical Ingredients (APIs) for chronic therapy.
Looking to source Domperidone Maleate or other high-quality pharmaceutical products? We’re here to help. Whether you need Active Pharmaceutical Ingredients (APIs), finished formulations, or regulatory support, our team is ready to provide dependable, compliant, and cost-effective solutions tailored to your market needs.